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Last Updated: 19/06/2024

Elucidation of drug resistance mechanism of Plasmodium falciparum from interaction with host vascular endothelium

Objectives

*Original title and abstract were machine translated from Japanese

This research aims to elucidate the drug resistance mechanism of Plasmodium falciparum from interaction with host vascular endothelium through culture experiments and animal experiments and lead to new treatments.

Principal Institution

Juntendo University, Japan

Principal Investigators / Focal Persons

Naoto Fukuda

Rationale and Abstract

There are five types of human malaria, depending on the type of parasite that infects them, but the most problematic is falciparum malaria. The reason is that falciparum malaria tends to become more severe, and parasites that are difficult to respond to drugs easily appear. Plasmodium falciparum infects human erythrocytes, but erythrocytes infected with Plasmodium falciparum have the property of adhering to the walls of blood vessels and blocking them. This impaired blood flow to organs is a major cause of severe malaria. From human research, it is suspected that adhesion may also be associated with another characteristic of this parasite, “drug resistance.”

External reference

Project details

Thematic Categories

Drug Resistance

Date

Apr 2022 — Mar 2025

Total Project Funding

$38,278

Funding Details

Japan Society for the Promotion of Science (JSPS), Japan

Grant ID: 22K15453

JPY 4.55M