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Last Updated: 19/06/2024
Elucidation of drug resistance mechanism of Plasmodium falciparum from interaction with host vascular endothelium
Objectives
*Original title and abstract were machine translated from Japanese
This research aims to elucidate the drug resistance mechanism of Plasmodium falciparum from interaction with host vascular endothelium through culture experiments and animal experiments and lead to new treatments.
There are five types of human malaria, depending on the type of parasite that infects them, but the most problematic is falciparum malaria. The reason is that falciparum malaria tends to become more severe, and parasites that are difficult to respond to drugs easily appear. Plasmodium falciparum infects human erythrocytes, but erythrocytes infected with Plasmodium falciparum have the property of adhering to the walls of blood vessels and blocking them. This impaired blood flow to organs is a major cause of severe malaria. From human research, it is suspected that adhesion may also be associated with another characteristic of this parasite, “drug resistance.”
Apr 2022 — Mar 2025
$38,278
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