Last Updated: 12/11/2024
Electrochemical Point-of-Care for the rapid and quantitative detection of malaria
Objectives
The main goal of this project is to develop a Point-of-Care (POC) device for the rapid diagnosis of malaria that, as a proof of concept, will detect Plasmodium antigens.
Despite the efforts of the international community, malaria remains a serious global health problem, with more than three billion people at risk of acquiring it worldwide and more than 200 million infections and 1 million deaths each. anus. Although eradicated from Europe in the 20th century, the globalization of population and merchandise flows, changes in the distribution of the mosquito vector due to climate change and the effects of the economic crisis threaten to reverse this situation. Spain has 5 million residents of foreign origin, one million annual trips by Spanish residents to tropical countries and the ravages of global warming and the crisis. Here, where the mosquito vector is widely established, 400-600 imported cases are reported annually and autochthonous cases were registered in 2010 and 2014. Faced with this situation, SNS professionals are not familiar with its diagnosis and do not have detection methods fast enough efficient. Researchers will employ magnetic particles and signal amplifiers to produce a simplified, ultra-fast, microfluidic assay on paper for easy assay performance and single-use printed electrodes for rapid, sensitive and quantitative detection. Compared to the currently available rapid assays, the proposed assay will be easier, more reproducible, and cheaper to produce, but at the same time will provide quantification of infection in 10-15 min with minimal user intervention, something that current tests do not provide.
Jan 2018 — Dec 2019
$92,437
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