Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Last Updated: 21/02/2025
Efficacy of chlorfenapyr-pyrethroid and PBO synergist-pyrethroid long-lasting insecticidal nets (LLINs) compared to pyrethroid-only LLINs for malaria control in Côte d’Ivoire: a three group, cluster-randomised trial
Objectives
The primary objective of this 2 years project is to evaluate the efficacy of chlorfenapyr-pyrethroid and piperonyl-butoxide (PBO) synergist-pyrethroid LLINs on malaria case incidence in children aged 6 months to 10 years compared to standard pyrethroid-only LLINs.
The secondary objectives are to evaluate the efficacy of the two intervention LLINs compared to the standard LLIN on
- malaria infection prevalence in the general population (both children and adults),
- vector density
- entomological inoculation rate (EIR) (as a proxy for malaria transmission).
In addition, changes in phenotypic resistance intensity and selection for molecular resistance mechanisms at baseline and 12 months post-LLIN distribution, in sentinel villages in each treatment arm will be investigate.
London School of Hygiene and Tropical Medicine (LSHTM), United Kingdom
The massive scale-up of long-lasting insecticidal nets (LLIN) has led to a major reduction in malaria burden in many sub-Saharan African (SSA) countries. This progress is threatened by the wide scale selection of insecticide resistant malaria vectors.
The investigator plan to conduct a three-arm cluster-randomized control trial which compares two next generation of long-lasting Insecticidal Nets (LLINs); Veeralin®LLIN (PBO-py LLIN), Interceptor G2 (chlorfenapyr-py LLIN) to a standard py-LLIN in the department of Tiebissou Southern Bouake city, central Côte d’Ivoire.
ClinicalTrials.gov ID NCT05796193
Three-arm superiority, single blinded, cluster-randomised trial with village as the unit of randomisation. The arms consist of; 1/ Veeralin LLIN, a net combining the synergist PBO and the pyrethroid alpha-cypermethrin, 2/Interceptor G2, a mixture LLIN incorporating two adulticides with different modes of action; chlorfenapyr and a pyrethroid (alpha-cypermethrin), and 3/ the control arm: MAGNet LLIN, an alpha-cypermethrin-only LLIN.
Apr 2023 — Apr 2025
Related Resources
