Does serum lipoproteins reduce malaria risk? Development into a new malaria control tool

Objectives

*Original title and text were machine translated from Japanese.

In this application, Juntendo University’s Department of Tropical Medicine is continuing to conduct research on cohorts in northern Uganda, in vitro culture systems, and infection experiments using mouse malaria to find out how it impacts risk.

Principal Institution

Juntendo University, Japan

Principal Investigators / Focal Persons

Yoshida Naoko

Partner Investigators

Takashi Miida
Toshihiro Mita

Rationale and Abstract

Malaria is one of the world’s three major infectious diseases. The applicant found that malaria-infected children have a high incidence of marked hypolipoproteinemia (low LDL and low HDL), and that lowering the lipoprotein concentration in culture experiments accelerated malaria proliferation. These results suggest that children with low serum lipoprotein levels may be more susceptible to malaria infection, but further support is needed through longitudinal epidemiological surveys and basic experiments in endemic areas.

External reference

Project details

Thematic Categories

Basic Science

Date

Apr 2023 — Mar 2026

Total Project Funding

$34,916

Funding Details

Japan Society for the Promotion of Science (JSPS), Japan

Grant ID: 23K09657

JPY 4.68M