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Last Updated: 31/01/2023
Discovery of new metabolic functions in Plasmodium parasites
Objectives
To accurately identify novel metabolites produced by the parasites, and discover the enzymes that are responsible for their synthesis by using use state-of-the-art metabolomics and proteomics technology.
This research will provide new understanding about the metabolism of parasites, such as those that cause malaria. These parasites have evolved bespoke metabolic networks to survive in diverse host environments including mosquitos and humans. Previous studies have revealed many unique genes and metabolites in these organisms, but their biochemical function is not known. This project will use state-of-the-art metabolomics and proteomics technology to accurately identify novel metabolites produced by the parasites, and discover the enzymes that are responsible for their synthesis. This work will not only advance our understanding of cellular metabolism, but will provide new opportunities for future biotechnology applications.
Jul 2022 — Jun 2026
$775,000
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