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Last Updated: 03/08/2023
Discovery of natural products isolated from fungal lineages as lead candidates for Malaria
Objectives
To identify and characterize new bioactive compounds isolated from fungal metabolites as lead candidates for the discovery of new antimalarials.
Principal Institution
Principal Investigators / Focal Persons
Rationale and Abstract
Malaria is a lethal parasitic disease with worldwide prevalence and despite investments in the search for new drugs, a high mortality rate is observed. The great structural diversity of natural products as well as their potent biological activities makes them attractive molecules for the discovery and development of new drugs. Among the microorganisms, fungi of different origins have been widely explored as producers of substances with antimalarial activity. The compounds will be prospected from fungal strains and their antiplasmodial and cytotoxic activities will be assessed in standardized in vitro and in vivo assays.
External reference
Thematic Categories
Date
Mar 2022 — Oct 2022
Funding Details
Foundation for research support in Sao Paulo (FAPESP), Brazil
Grant number : 22/01066-4
Project Site
Related Resources
