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Last Updated: 30/08/2024
Development of novel therapeutic strategies using multifunctional red blood cells induced by engineered malaria parasites
Objectives
*Original title and text were machine translated from Japanese.
This research focuses on creating innovative therapeutic strategies by modifying malaria parasites to enhance red blood cells’ ability to self-assemble at tumor sites using multifunctional red blood cells induced by engineered malaria parasites.
Malaria parasites infect red blood cells and express molecules on their surface that allow them to adhere to other cells. In this study, parasites with an artificially modified PfEMP1 were used which is involved in adhesion, to give red blood cells the ability to self-assemble at lesions such as tumors. It is expected that this will enable red blood cells to become a completely new therapeutic tool, for example by filling up the blood vessels that nourish tumors and blocking blood flow, or by producing and secreting anti-tumor molecules on the spot to directly attack lesions.
Apr 2023 — Mar 2029
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