Development of a new rotavirus-vectored oral malaria vaccine

Objectives

The objectives of this study are to:

1. develop an orally administered multistage malaria vaccine loaded with multiple P. falciparum antigens using rotavirus as a vector;
2. create an orally administered multistage vaccine utilizing rotavirus as a delivery vector;
3. evaluate the immunogenicity and antimalarial effects of the developed vaccine—both its transmission-blocking and infection-protective capabilities—using culture and mouse models;
4. assess the synergistic effects of the vaccine at multiple stages of malaria infection; and
5. elucidate the mechanism of action underlying the vaccine’s protective and transmission-blocking effects.