Last Updated: 20/08/2024
Detailed mechanism of trafficking proteins involved in the virulence of Plasmodium falciparum
Objectives
*Original title and text were machine translated from Japanese.
This study will analyze how the proteins responsible for Maurer’s fissure, a protein transport system are involved in the pathogenesis of malaria.
Malaria is a circulatory disease caused by a protozoan that is transmitted to humans by mosquito blood, and its main symptom is anemia due to the proliferation and destruction of the protozoan within red blood cells. It forms a unique vesicular organelle called “Maurer’s fissure” within malaria-infected red blood cells, and functions as a protein transport system within infected red blood cells, such as transporting pathogenic proteins derived from the protozoa to the red blood cell surface. Using this protein transport system, the protozoan proteins presented on the membrane of infected red blood cells bind to the capillary wall, other infected red blood cells, and uninfected red blood cells to form cell clusters called “rosettes,” thereby occluding blood vessels. This leads to severe disease by causing multiple organ failure.
Mar 2023 — Mar 2024
$17,160
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