DEEP DIVE

Malaria Molecular Surveillance (MMS)

Creation date:

18/07/2024

Last modified date:

26/02/2025

This is an active Deep Dive and we welcome your contributions! If you are currently involved in or planning a malaria molecular surveillance project, please contact MESA (mesa@isglobal.org) or add your project to the MESA Track database.

——

Malaria Molecular Surveillance (MMS) – The use of molecular biology approaches, from serology to genotyping to whole genome sequencing, to study malaria parasites and vector populations in order to derive epidemiologically actionable information.

MMS has great potential to improve malaria surveillance efforts. However, there is a considerable gap in transforming this potential and aligning MMS efforts to public health needs to enable country-led analysis and decision-making.

This Deep Dive, categorized by use cases, has an overarching aim to map out who is doing what, where, and how to facilitate coordination and information sharing to bridge the gap between MMS initiatives and their use in informing policy and programmatic decision-making.

Several use cases have been identified for MMS:

  1. Drug resistance (Monitoring antimalarial drug resistance, emergence and spread)
  2. Pfhrp2/3 gene deletions (Monitoring gene deletions, emergence and spread)
  3. Therapeutic efficacy study (TES) classification (Recrudescence vs new infections)
  4. Plasmodium species diversity 
  5. Connectivity of parasite strains and gene flow, case classification (local/imported) and transmission sources
  6. Stratification of malaria burden and changes in transmission (Transmission intensity, dynamics/patterns & evolution)
  7. Immune escape (vaccines & mAbs)
  8. Insecticide resistance (Monitoring insecticide resistance, emergence and spread)
  9. Vector species identification, diversity and distribution 
  10. Resistance to gene drive (Monitoring allelic variation in target sites for gene drive)

 

Explore the projects in this Deep Dive as well as the MESA collection of resources on MMS. Share your contributions by writing to mesa@isglobal.org.

MESA Track
Total
projects

0 active
MESA Track
Total funding
amount

MESA Track
Project
sites

Use Cases

Total Projects

Project Timeline

Use Cases

Total Projects

    Project Timeline

    Use Cases

    Total Projects

      Project Timeline

      FILTERS
      $0M
      $250M

      Reset filters
      Principal Institutions
      Projects|Funding



      Principal Investigators

        Funding Sources

        Principal Institutions

        Principal Investigators

        Funding Sources

        Principal Institutions


        Latest projects