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Last Updated: 02/08/2024
Creation study of cyclic peptide libraries of antimalarial active lipopeptides using aqueous tags
Objectives
*Original title and text were machine translated from Japanese.
This project aims to explore cyclic peptide libraries of antimalarial active lipopeptides using aqueous tags.
Malaria is one of the world’s three major infectious diseases caused by Plasmodium falciparum, and although various therapeutic drugs have already been developed, the emergence of resistant parasites has led to the need for new therapeutic drugs. development is necessary. Therefore, the focus was on lipopeptides that showed antimalarial activity comparable to existing drugs, and decided to aim to develop a new oral treatment for malaria, taking into account the sanitary and economic conditions of endemic areas. In addition, since cyclization of peptides is known to be useful as an oral drug, the possibility of efficiently converting the lipopeptide into a cyclized form as a new oral therapeutic agent for malaria will be investigated.
Apr 2023 — Mar 2025
$34,913
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