Last Updated: 03/08/2023
Correlation between systemic changes induced by Plasmodium vivax infection in humans in the tapajós river extension and a murine model of experimental Plasmodium yoelli malaria: A Translational Study
Objectives
*Original title in Portuguese: Correlação entra as alterações sistêmicas induzidas pela infecção por Plasmodium vivax em humanos na extensão do rio tapajós e modelo murino de malária experimental por Plasmodium yoelli: Um Estudo Translacional
This project seeks to correlate changes in humans with malaria induced by Plasmodium vivax along the Tapajós river with a murine model of experimental vivax malaria induced by Plasmodium yoelli, seeking a possible protective effect of Mauritia flexuosa L (Buriti).
Pará is a state located in the north of the country which, due to its various intrinsic and extrinsic factors, is characterized as an endemic area for diseases such as malaria. Malaria is an infectious disease, considered one of the main endemic diseases in the world and a major obstacle to the economic development of communities and nations, with high morbidity and mortality rates, similar to other infectious diseases such as tuberculosis and HIV/AIDS. In Brazil, 99.7% of registered cases of malaria are found in the Amazon region. In Pará, although there was a 46% reduction in malaria cases in 2020 compared to the same period in 2019, there was a 15.2% increase in transmission in riverside communities located along the Tapajós River (West of the State of Pará ). In addition, vivax malaria can induce oxidative stress, making it essential to use molecules with antioxidant properties as possible pharmacological tools in this situation.
Jan 2022
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