Last Updated: 26/09/2023
Computational studies, synthesis and pharmacological evaluation of novel phthalimide derivatives for the treatment of Malaria
Objectives
This project aims to carry out the virtual screening of 48 phthalimide derivatives with potential antimalarial activity and then synthesize the 8 most promising ones for further pharmacological evaluation.
Principal Institution
Principal Investigators / Focal Persons
Rationale and Abstract
Malaria is caused by species of Plasmodium spp. It is estimated that 228 million cases and 405 thousand deaths were reported worldwide in 2018 due to this disease. In addition, the parasites are acquiring resistance to the drugs currently available for treatment. Therefore, it is extremely urgent to develop novel drugs candidates against this disease.
External reference
Thematic Categories
Date
Aug 2021 — Jul 2022
Funding Details
Foundation for research support in Sao Paulo (FAPESP), Brazil
Grant number: 21/03565-5
Project Site
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