Last Updated: 24/04/2023

Chemoprevention Efficacy Study in Burkina Faso

Objectives

  1. To determine whether Seasonal Malaria Chemoprevention (SMC) remains effective in the health district of Nanoro in the Centre-Ouest region or Boussé in the Plateau Central region.
  2. To assess the protective efficacy of the antimalarial drugs used in SMC in the target population and to investigate levels of parasite resistance in the study districts.
Principal Institution

Malaria Consortium, United Kingdom

Principal Investigators / Focal Persons

Gauthier Tougri

Rationale and Abstract

This cohort study aims to evaluate the effects of a clinical intervention on relevant outcomes whilst collecting information on implementation.

The study uses pragmatic implementation research with the objective of contributing to the development of practical recommendations for health policy, practice and potential scale up. It is designed as an implementation study to determine effectiveness and protective efficacy to gather evidence of the potential impact on health outcomes. Five monthly cycles of SMC will be implemented between July and October 2022 in one district, Nanoro, in Centre Ouest region.

The study will comprise the following two components:

  1. A prospective protective efficacy cohort study to determine if SPAQ provides 28 days of protection from infection and whether drug concentrations and/or resistance influence the duration of protection
  2. A resistance markers study in children 3-59 months in the two research districts plus the two standard intervention districts to measure changes in resistance marker prevalence over time (pre and post within the same year and between years)
Study Design
  • Allocation: N/A
  • Intervention Model: Single Group Assignment
  • Intervention Model Description: Cohort
  • Masking: None (Open Label)
  • Primary Purpose: Prevention

ClinicalTrials.gov Identifier: NCT05478954

Date

Jul 2022 — Oct 2022

Total Project Funding

$300,000

Funding Details
Malaria Consortium, United Kingdom

Study ID Numbers: SMCBFPHASE1
Project Site

Burkina Faso

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