Characteristics and outcomes of patients with COVID-19 admitted to the ICU

In December 2019, an outbreak of Severe Acute Respiratory Syndrome (SARS) attributed to a new coronavirus, called SARS-CoV-2, was described in the Wuhan region of China. This SARS, caused by SARS-CoV-2 was called COVID-19, spread across the globe, causing millions of cases on all continents, and thousands of deaths, being characterized as a pandemic.

COVID-19 is characterized by a flu-like syndrome, with symptoms such as fever, cough, myalgia and gastrointestinal symptoms. Most cases are mild, some even asymptomatic, but approximately 15% of patients have more severe presentation, and approximately 5% are critical.

The acute respiratory failure of critically ill patients with COVID-19 has different aspects, including hypoxemia of difficult treatment, associated in some cases with clotting disorders, changes in immunity and inflammatory phenomena that pose challenges for the management of these patients, whose mortality can be high.

The Hospital das Clínicas da Faculdade de Medicina de São Paulo implemented an action plan that provides for the creation of 200 ICU beds to serve patients with COVID-19. Knowing the characteristics of critically ill patients with COVID-19 and their clinical outcomes is extremely important to inform clinical decision-making and to guide the strategy to mitigate the epidemic, both within each hospital and ICU and in public health management.

Observational; Case-Series

Primary Outcome Measures  :
ICU survival at 28 days [ Time Frame: 28 days ]
Proportion of patients who survive to ICU discharge or for 28 days in the ICU

Secondary Outcome Measures  :
Hospital survival at 60 days [ Time Frame: 60 days ]
Proportion of patients who survive to hospital discharge or for 60 days in the hospital

Duration of mechanical ventilation [ Time Frame: 28 days ]
Number of days under invasive ventilatory support

Need for renal replacement therapy [ Time Frame: 28 days ]
Proportion of patients who received renal replacement therapy during the ICU stay

Complications during the ICU stay [ Time Frame: 28 days ]
Percentage of patients who developed complications during the ICU stay: thromboembolic events, ventilator associated pneumonia, secondary infections, cardiovascular complications

Clinical Trials Registration NCT04378582

Monitoring & Evaluation
Vulnerable Populations

May 2020 — Dec 2020

Brazil

Clinical Epidemiology of COVID-19 in Malaria Settings