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Last Updated: 03/03/2023
Blocking malaria transmission and infection
Objectives
To reveal how Plasmodium falciparum governs host tropism, fertilization and immune evasion by using the 6-cysteine family of proteins which are abundantly expressed on its surface.
Principal Institution
Walter and Eliza Hall Institute of Medical Research (WEHI), Australia
Principal Investigators / Focal Persons
Rationale and Abstract
Plasmodium falciparum is the most lethal malaria parasite that infect humans. This proposal will explore novel ways using the smallest types of antibodies, called nanobodies, to block the function of these proteins and therefore prevent malaria infection.
Project Outputs
Article: Plasmodium 6-Cysteine Proteins: Functional Diversity, Transmission-Blocking Antibodies and Structural ScaffoldsArticle: Nanobodies against Pfs230 block Plasmodium falciparum transmission
External reference
Thematic Categories
Date
Jan 2021 — Dec 2025
Total Project Funding
$909,621
Funding Details
National Health and Medical Research Council (NHMRC) Australia, Australia
Grant number: 2001385
Project Site
Related Resources
