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Last Updated: 05/10/2023
Biomarkers, immune response and mechanisms associated with protection or morbidity in protozoan infections: Leishmania, Plasmodium, Trypanosoma cruzi and Toxoplasma gondii
Objectives
This is an “umbrella” project that houses sub-projects with the objectives of:
- Identify morbidity biomarkers in malaria caused by Plasmodium vivax: inflammatory mediators and miRNA;
- Study the immune response and mechanisms associated with protection and morbidity in Plasmodium infections in populations exposed to malaria;
- Identify and carry out the immunological characterization of B and T cell epitopes in Plasmodium sp. and its implications in vaccine processes;
- Identify modulators in the immune response in Chagas disease and Leishmaniasis;
- Study the role of CD4-CD8- T cells in Chagas disease
- Study of the role of extracellular networks of T lymphocytes (LETs) and “tissue resident macrophages” in leishmaniasis;
- Study the immune response in toxoplasmosis.
Principal Institution
Principal Investigators / Focal Persons
External reference
Thematic Categories
Basic Science
Combination of Interventions
Vaccines (Immune Correlates)
Date
Jan 2021
Funding Details
Coordination for the Improvement of Higher Education Personnel (CAPES), Brazil
Grant number: 696269
Project Site
Related Resources
