Last Updated: 25/08/2017
Assessing the impacts of insecticide resistance on vectorial competence of Anopheles gambiae from Uganda
Objectives
To understand how insecticide resistance mutations in mosquitoes impact the transmission of malaria in a highly endemic region of Uganda by determining the prevalence and mean intensity of P. falciparum infection in insecticide-resistant and susceptible mosquitoes.
Liverpool School of Tropical Medicine (LSTM), United Kingdom
Malaria in Sub-Saharan Africa is caused by Plasmodium species, in particular, P. falciparum, transmitted by the mosquito vector, Anopheles gambiae. Anti-vector strategies for controlling mosquito populations rely on the use of insecticides. Unfortunately, An. gambiae has developed intense insecticide resistance that not only prevents their killing but also may impact their physiology and susceptibility to infection with P. falciparum. Studies assessing infection in insecticide-resistant mosquitoes are needed urgently.The transmission of the human malaria parasite, P. falciparum by An. gambiae remains a crucial step yet weak point in the life cycle of the parasite. Certain factors can affect this process; For instance, mutations causing insecticide resistance may make mosquitoes more susceptible to human malaria parasites leading to increased transmission.
Sep 2016 — Mar 2019
$137,459
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