Last Updated: 01/08/2024
Antibodies, white blood cells and protection from severe malaria
Objectives
This proposal aims to identify the most dangerous PfEMP1 types, and the most protective antibodies, using samples from severe and mild malaria and also study how such antibodies develop, and how they function.
Principal Institution
Principal Investigators / Focal Persons
Rationale and Abstract
This study focuses on antibodies that recognise PfEMP1s, proteins expressed on malaria infected red blood cells. Unusually, PfEMP1 antibodies often lack a key sugar. The deadly PfEMP1 types will then be studied with white blood cells, which can clear or kill the parasites. This work may lead to a PfEMP1 vaccine.
External reference
Thematic Categories
Date
Jan 2024 — Dec 2026
Total Project Funding
$689,283
Funding Details
National Health and Medical Research Council (NHMRC) Australia, Australia
Grant ID: 2029642
AUD 1.02M
Project Site
