Last Updated: 12/08/2025
Elucidation of the adhesion mechanism between monkey malaria parasite molecules and human vascular endothelial cells
Objectives
*Original title and text were machine translated from Japanese.
This study will analyze which part of the SICA-HUVEC molecule is involved in adhesion to human vascular endothelial cells, and further explore the receptor on human vascular endothelial cells to which SICA-HUVEC binds.
Principal Institution
Principal Investigators / Focal Persons
Rationale and Abstract
The malaria parasite Plasmodium knowlesi, whose natural host is the macaque monkey that inhabits Southeast Asia, is known to infect humans and cause P. vivax malaria, which can sometimes lead to severe illness or death. The principal investigators have previously identified the P. knowlesi parasite molecule SICA-HUVEC, which is involved in adhesion to human vascular endothelial cells.
External reference
Themes
Date
Apr 2025 — Mar 2028
Total Project Funding
$30,892
Funding Details
Project Site
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