Last Updated: 15/07/2025
Clinical and immunological consequences of natural routes of infection in a murine model of tuberculosis-malaria co-infections
Objectives
This project will develop a novel mouse model using aerosol-delivered Mycobacterium tuberculosis and Plasmodium transmission by mosquito bite to uncover how co-infection, host sex, and environmental stressors shape pathogen burden, immune pathology, and survival.
Principal Institution
Principal Investigators / Focal Persons
Rationale and Abstract
Tuberculosis and malaria are leading causes of morbidity and mortality in low-resource settings, yet little is known about how co-infection alters disease outcomes, especially through natural routes of infection. Findings will inform integrated strategies for vaccine and drug development in populations disproportionately affected by both diseases.
Themes
Date
Jul 2023 — Jun 2024
Total Project Funding
$50,000
Funding Details
Project Site
Related Resources
