Guidelines for risk analysis for the testing and deployment of genetically modified mosquitoes

The layout of the Guideline entails Risk Analysis for GMM covering background information current research methods for controlling malaria covering two malaria GMM control strategies- population suppression population replacement. It describes the phased approach, which is a highly recommended framework for the development and deployment of GMM and covers key components of Risk Analysis. It provides a two-fold approach to Risk analysis to produce safety data needed for deployment of the technology and moving from one phase to the next. It also describes risk analysis procedures needed to ensure that the research is conducted in a safe manner for human health, animal health and the environment. To complement the risk analysis, the guideline outlines how mathematical models could be used to augment risk analysis.

This Risk Analysis Guideline is a guiding document for researchers, regulators and other policy makers involved in GMM research in Africa. It consists of five main categories of topics. First, an introduction to the importance of malaria in Africa and the need to augment all several available tools for its control and elimination. Second, it is an outline of the phased approach to research and deployment of GMM in Africa that is recommended and should be adhered to. Third, it outlines the components of Risk Analysis and its relevance to GMM in Africa. Fourth, it describes how Risk analysis interphases with each phase of GMM product development and deployment steps. Fifth, it outlines the use of mathematical modelling in enhancing the process of Risk analysis.