Last Updated: 25/03/2025
Biogenesis of extracellular vesicles from Plasmodium-infected RBC and impact on pathogenesis, parasite communication and transmission
Objectives
The aim of this project is to determine how REVs are generated in a malaria infection, knowledge of which is essential for determining if these pathways can be exploited for preventing and/or treating severe disease.
Principal Institution
Principal Investigators / Focal Persons
Rationale and Abstract
During a malaria infection, extracellular vesicles are released from infected red blood cells (termed REVs) to modulate the host immune response and to facilitate cell-cell communication. Increased REV levels correlate with disease severity.
External reference
Themes
Date
Jan 2025 — Dec 2027
Total Project Funding
$551,179
Funding Details
National Health and Medical Research Council (NHMRC) Australia, Australia
Grant ID: 2037604
AUD 838,138
Project Site
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