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Last Updated: 07/02/2025
Understanding cell polarity & organelle biogenesis in parasites of mammals
Objectives
This project will investigate two evolutionarily divergent parasites: Plasmodium, a mosquito-transmitted parasite that causes malaria, and Cryptosporidium, a gastrointestinal parasite. It will determine when, where and how these parasites establish their polarity and build their apical organelles, and whether these pathways are evolutionarily conserved.
Principal Institution
Principal Investigators / Focal Persons
Partner Investigators
Rationale and Abstract
Single-celled parasites cause economically significant diseases in both humans and livestock. These parasites undergo a complex process to build the organelles that control their entry into host cells at their apical end, making the parasites hyper-polarised. Despite their importance, the proteins that control polarity establishment and apical organelle biogenesis are not known.
External reference
Thematic Categories
Date
Jan 2025 — Dec 2027
Total Project Funding
$361,266
Funding Details
Project Site
Related Resources
