Last Updated: 29/01/2025
Development of experimental model for surface antigens of human malaria parasite
Objectives
*Original title and text were machine translated from Japanese.
This study will:
- Create recombinant rodent malaria parasites that express red blood cell surface antigens of Plasmodium falciparum, and
- Attempt to create mice that express human target molecules, and develop an animal model of malaria focusing on surface antigens.
When Plasmodium falciparum infects red blood cells, it displays its own proteins on the surface of infected red blood cells to evade and suppress host immunity. However, since this protozoan only infects humans, it is not possible to evaluate its function in vivo. In contrast, in this study, it was attempted to (1) create a recombinant murine malaria parasite that expresses the red blood cell surface antigen of Plasmodium falciparum, and (2) create a mouse that expresses a human target molecule. This will solve the aforementioned technical issues and contribute to the development of vaccines and therapeutic drugs that target surface antigens.
Jun 2022 — Mar 2024
$46,703
Related Resources
