Last Updated: 01/08/2024
Na(+)-dysregulating antimalarials: blocking the roads to resistance by understanding PfATP4 and its place in parasite physiology
Objectives
This project aims to understand the ways in which parasites can protect themselves from Cipargamin, and explore strategies for preventing resistance. It will further characterise other proteins that regulate salt balance in malaria parasites.
Principal Institution
Principal Investigators / Focal Persons
Rationale and Abstract
The most deadly malaria parasite has acquired resistance to most antimalarials, and there is a danger of malaria becoming an untreatable disease. Cipargamin is a promising new antimalarial that targets a protein needed for salt balance in the parasite.
External reference
Thematic Categories
Date
Jan 2024 — Dec 2027
Total Project Funding
$565,933
Funding Details
National Health and Medical Research Council (NHMRC) Australia, Australia
Grant ID: 2028714
AUD 837,718
Project Site
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