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Last Updated: 01/08/2024

Defining new mechanisms of action and resistance for the malaria drug proguanil

Objectives

This project addresses the need to understand how existing malaria drugs work by investigating the mode of action and potential resistance mechanisms of the antimalarial drug proguanil.

Principal Institution

Griffith University, Australia

Principal Investigators / Focal Persons

Katherine Andrews

Rationale and Abstract

Malaria causes >200 million clinical cases and >600,000 deaths annually. There is no broadly effective malaria vaccine and drug resistance is a significant global problem. Thus, it is essential that current drugs are used effectively to limit parasite resistance development and to ensure their continued use.

External reference

Project details

Thematic Categories

Drug Resistance
Drug-based Strategies

Date

Jan 2024 — Mar 2027

Total Project Funding

$561,608

Funding Details

National Health and Medical Research Council (NHMRC) Australia, Australia

Grant ID: 2029164

AUD 831,316