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Last Updated: 02/08/2024
Characterization of distinct immune memory development by route of immunization of mRNA containing lipid nanoparticles
Objectives
*Original title and text were machine translated from Japanese.
The purpose of this study is to clarify the mechanism by which different types of memory cells are preferentially induced in the liver by different routes of mRNA-LNP administration.
There is an urgent need to develop an effective malaria vaccine. Since hepatocytes are the first target, efficient induction of cellular immunity in the liver is very important in malaria elimination. In recent years, it has been revealed that liver-resident memory CD8 T cells (TRM) act in the defense against malaria infection. The applicant is engaged in malaria vaccine development and has established a method to efficiently induce TRM in the liver using mRNA-containing lipid nanoparticles (mRNA-LNP). During this process, it became clear that the types of memory cells induced in the liver differ depending on the route of mRNA-LNP administration.
Apr 2023 — Mar 2025
$34,913
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