Last Updated: 26/02/2024
Can piperonyl butoxide (PBO) insecticide treated nets (ITNs) be an effective vector control tool in Ethiopia? If justified, can it eventually replace IRS?
Objectives
The primary objectives of this study are:
- To evaluate the relative impacts of (1) PermaNet 3.0 PBO ITNs alone and (2) a combined intervention IRS using pirimiphos-methyl plus standard pyrethroid ITNs (IRS + Std ITN) on malaria case incidence in a low to very low malaria transmission setting with mixed parasite circulation;
- To evaluate the relative impacts of (1) PermaNet 3.0 PBO ITNs alone and (2) a combined intervention IRS using pirimiphos-methyl plus standard pyrethroid ITNs (IRS + Std ITN) on indoor host-seeking density of Anopheles mosquitoes in a low to very low malaria transmission setting with mixed parasite circulation.
- To determine whether the impact of PermaNet 3.0 PBO ITNs alone on malaria case incidence is not significantly less than the impact of IRS with pirimiphos-methyl plus standard ITNs.
The secondary objective of this study is:
- To evaluate the relative impacts of (1) PermaNet 3.0 PBO ITNs alone and (2) a combined intervention IRS using pirimiphos-methyl plus standard pyrethroid ITNs (IRS + Std ITN) on selected entomological indices of malaria transmission, including sporozoite infection rate.
Principal Institution
Principal Investigators / Focal Persons
Rationale and Abstract
This study aims to provide the Ethiopia NMEP and other key stakeholders with clear evidence regarding the relative impacts of two major community-level malaria intervention strategies. Specifically, it will provide evidence as to whether the deployment of PBO ITNs without IRS provides comparable protection to IRS with the concomitant distribution of standard ITNs. This will help the NMEP and other stakeholders to better prioritize available resources to meet malaria control needs.
Thematic Categories
Date
Jun 2021 — Feb 2022
Funding Details
Project Site
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