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Last Updated: 26/01/2024
Dynamics of natural immunity to malaria in adults (DYNAMIA)
Objectives
The following are the study’s four primary objectives:
- Characterizing the temporal dynamics of naturally acquired asymptomatic and symptomatic malaria parasitemia in adults residing in areas of high, low, and moderate malaria exposures in Bagamoyo, Tanzania.
- Characterizing the cellular and humoral markers of malaria immunomodulation in adults living in areas with low, moderate, and high malaria exposure in Bagamoyo, Tanzania.
- Developing a registry of approximately 450 potential research participants with well-characterized malaria exposure and immune profiles for participation in the trials of the next-generation malaria vaccine in Bagamoyo, Tanzania.
- Establishing a repository of biospecimens for future use in exploring the cellular and humoral immune responses to advance our understanding of malaria immunity and inform the development of malaria vaccines in adults.
Malaria infection is still responsible for millions of clinical cases and hundreds of thousands of deaths yearly, with the highest burden being reported in children under five years of age. Despite a tremendous effort to fight against malaria infection worldwide, the malaria burden has recently plateaued or even increased in some parts of the endemic regions. One of the causes of poor immunogenicity is thought to be immunomodulation due to not only malaria parasite exposure but also persistence of asymptomatic parasitemia. A cohort that concurrently follow participants in areas of low to high malaria exposure offers a unique opportunity to understand these changes. A well-characterized cohort in terms of malaria exposure and other relevant factors will also provide a database of potential participants for the next-generation malaria vaccine developed for adults. The project aims to determine the long-term malaria exposure status in adults residing in areas of low, moderate, and high malaria transmission and investigate the interplay between parasite exposure and malaria-related immunosuppression to inform next- eneration malaria vaccine develo ment for adults in malaria-endemic countries.
Oct 2023 — Jun 2027
$4.04M
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