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Last Updated: 21/10/2024
Targeting acute kidney injury in knowlesi malaria
Objectives
This study will conduct a randomised clinical trial to assess whether paracetamol can reduce kidney dysfunction in knowlesi malaria, by inhibiting oxidative damage caused by the breakdown of red blood cells.
Principal Institution
Principal Investigators / Focal Persons
Rationale and Abstract
To-date >330 Malaysian adults and children have been randomly assigned to receive either regularly-dosed paracetamol or no paracetamol, together with anti-malarial treatment. The primary endpoint is change in kidney function at 72 hours, in patients who received paracetamol vs. no paracetamol.
Project Outputs
Article: Osteoprotegerin (OPG) and its ligands RANKL and TRAIL in falciparum, vivax and knowlesi malaria: correlations with disease severity, and B cell production of OPGArticle: Longitudinal changes in iron homeostasis in human experimental and clinical malaria
External reference
Thematic Categories
Date
Jan 2019 — Dec 2020
Total Project Funding
$231,526
Funding Details
National Health and Medical Research Council (NHMRC) Australia, Australia
Grant ID: 1156809
AUD 333,082
Project Site
Deep Dives
