Production and infection platform Nyssorhynchus darlingi – experimental model for studying the pathogen-vector relationship (Plasmodium vivax – Ny. darlingi) for the development of control strategies in brazil

Nyssorhynchus darlingi is the main vector in the Amazon region and one of the transmitters of Plasmodium spp. most efficient in the world. In the Amazon, this is considered the primary vector in almost all states, being highly competent in the process of transmitting the parasite to the human host. Intervention methods for malaria control, targeting the invertebrate host, whether through the use of insecticides, sporogonic cycle blockers, or exoerythrocytic blockers, represent a major challenge for the scientific and health community. Since, the rapid emergence and spread of insecticide-resistant mosquitoes and the scarcity of transmission blocking drugs aggravate this scenario. In this sense, the establishment of a mass creation of anopheles in the laboratory is extremely necessary and represents a primary condition for the development of malaria research in a multidisciplinary context. Therefore, the Entomology group (Fiocruz Rondônia) was the second laboratory in the world to establish a highly productive colony in Ny. darlingi. This is a multidisciplinary project that has the partnership of important centers, such as: FIOCRUZ, London School, National Institute of Health, Harvard and University of São Paulo.

Project details

Combination of Interventions

Jan 2020 — Dec 2022

Brazil