Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Warning: Undefined array key "file" in /var/www/vhosts/gestortectic.com/mesa.gestortectic.com/wp-content/plugins/fulltext-search/includes/wpfts_querylog.php on line 520
Last Updated: 19/10/2023
SAILing around the most abundant chemical elements in Life: development of bioactive Surface-Active Ionic Liquids by combination of antimalarial drugs with natural lipids
Objectives
This study aims at the development of bioactive Surface-Active Ionic Liquids (SAIL) by combination of antimalarial drugs with natural lipids.
Principal Institution
Principal Investigators / Focal Persons
Rationale and Abstract
Inspired by previous disclosure of room-temperature ionic liquids derived from primaquine and cinnamic acids, which displayed slightly enhanced blood-stage activity compared to the parent drug, this study has now combined this emblematic antimalarial with natural fatty acids. This affords surface-active ionic liquids whose liver-stage antiplasmodial activity is either retained or slightly enhanced, while revealing blood-stage antiplasmodial activity at least one order of magnitude higher than that of the parent compound. These findings open new perspectives towards the cost-effective recycling of classical drugs that are either shelved or in decline, and which is not limited to antimalarial agents.
External reference
Thematic Categories
Date
Jul 2020 — Mar 2023
Total Project Funding
$3,360
Funding Details
Foundation for Science and Technology (FCT), Portugal
Grant number : 77952DFAProjectReference : SFRH/BD/150649/2020
2,948 EUR
2,948 EUR
Project Site
Related Resources
