Last Updated: 18/06/2024
Physiological mechanisms of membrane structures in P. falciparum gametocytes
Objectives
To elucidate the physiological significance of membrane structures newly formed within the cytoplasm of red blood cells by P. falciparum gametocytes.
In this study, the principal investigators identified the conditions under which Plasmodium falciparum gametocytes efficiently form gametocytes. The membrane structures in erythrocytes infected with Plasmodium falciparum gametocytes were subsequently observed by electron microscopy. The results showed that infected erythrocytes have a characteristic membrane structure that differs from that of Plasmodium falciparum cells. Several plasmids for knockdown of proteins transported to erythrocytes during the gametocyte stage and translocon constituent proteins were generated and transfected, and analysis of the genetically modified Plasmodium is currently underway.
Sep 2020 — Mar 2022
$25,872
