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Last Updated: 06/09/2024
NOMADS II: Expanding nanopore sequencing of malaria
Objectives
The main objectives of this project are:
- Integrate nanopore sequencing into routine surveillance in Zambia;
- Expand nanopore sequencing to new geographies through collaboration and capacity building; and
- Optimize existing and develop novel nanopore sequencing assays for malaria molecular surveillance.
Principal Institution
Principal Investigators / Focal Persons
Partner Investigators
Rationale and Abstract
With support from the Bill and Melinda Gates Foundation (BMGF), the NMEC Oxford Malaria Amplicon Drug-resistance Sequencing (NOMADS) team developed a cost-effective and scalable testing material (known as an assay) for antimalarial drug resistance in P. falciparum that uses a technique called nanopore sequencing. When the team tested the assay at the Zambian Ministry of Health’s National Malaria Elimination Centre (NMEC), they demonstrated that rapid in-country sequencing to identify antimalarial drug resistance was not only possible, but also required minimal infrastructure, allowing for the detection of drug resistance to happen closer to where policies and decisions are made.
Project Outputs
External reference
Thematic Categories
Capacity Building
Drug Resistance
Enabling Technologies & Assays
Health Workforce
Surveillance
Date
Nov 2022 — Dec 2025
Total Project Funding
$3.73M
Funding Details
Bill and Melinda Gates Foundation (BMGF), United States
Grant ID: INV-048316
Project Site
Deep Dives
Related Resources
