Last Updated: 18/06/2024

Pharmacological properties of triple antimalarial drug combinations in malnourished children

Objectives

To evaluate the pharmacokinetic properties of triple-artemisinin combination therapies (TACTs) in the critical population of malnourished children, with the aim of understanding the complex relationship between malnutrition and drug efficacy.

Principal Institution

Doctors Without Borders (MSF), Switzerland

Principal Investigators / Focal Persons

Rebecca Grais

Rationale and Abstract

Malaria remains a key driver of high mortality in sub-Saharan Africa, particularly in Niger. Malnourished children are particularly vulnerable to malaria, and more likely to die from it. Malaria drug resistance to several commonly used drugs has emerged and spread. As a new approach to treat multi-drug resistant malaria, we have proposed to increase the number of drugs to 3 in malaria treatments (i.e. triple-artemisinin combination therapies, TACTs). Epicentre Niger is one site in a multicentre RCT evaluating TACTs, and is uniquely placed given the high rate of malnutrition. This funding will specifically target aid for a vulnerable and neglected population, while providing evidence to reduce the impact of two of the most devastating crises in the region.

External reference

Project details

Thematic Categories

Drug-based Strategies

Date

Sep 2021 — Oct 2022

Total Project Funding

$639,814

Funding Details

Wellcome Trust, United Kingdom

Grant ID: 222740/Z/21/Z

GBP 476,489