Last Updated: 18/06/2024
Malaria drug resistance in Brazil
Objectives
The aims of this project are;
1) to perform genomic analysis of infections from drug resistance foci, searching for specific mutation patterns in drug resistance genes.
2) to test the new antimalarial KAF156, a future option for artemisinin resistant settings, in Brazilian culture adapted P. falciparum.
3) to study of the diversity of pvcarl, a potential marker of KAF156 resistance in Plasmodium vivax, as this drug is also aimed for P. vivax malaria.
The Brazilian northern borders are a focus of malaria drug resistance, including artemisinins. The researchers will gather information for a better management of these resistance infections, including testing a next generation antimalarial. The project will set the basis for further collaborative research in malaria drug resistance between the two institutions. The northern borders of Brazil are a craddle for drug resistance malaria, especially among the elusive communities of illegal miners. These resistant parasites are a public health danger for Brazil.In this researcher exchange program the researchers will study the genomes of these special parasites, looking for special mutations associated with resistance, while testing KAF156, a new antimalarial under development as an alternative to manage drug resistant malaria.
Dec 2021 — Nov 2022
$80,757
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