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Last Updated: 03/08/2023
The role of mechanosensing and antibodies for interactions of Plasmodium sporozoites with neutrophils in 3D environments (22*)
Objectives
To quantify through in vivo imaging and by using a novel 3D skin mimetic system if and how antibodies modulate neutrophil-sporozoite interaction.
Principal Institution
University of Heidelberg, Germany
Heidelberg University Hospital, Germany
Principal Investigators / Focal Persons
Rationale and Abstract
During transmission of malaria, Plasmodium sporozoites rely on the surface protein TRAP for migration through the skin and entry into the liver. Sporozoites can migrate on many surfaces, but surprisingly not on endothelial cells or soft gels. The study will investigate whether TRAP binds multiple or specific ligands and con-tributes to sensing substrate stiffness. Sporozoites can be immobilized by antibodies and targeted by neu-trophils in the skin.
External reference
Thematic Categories
Date
Jan 2022
Funding Details
German Research Foundation (DFG), Germany
alternative grant number : SFB 1129 22*Grant number : 506439730
Project Site
Related Resources
