Last Updated: 19/06/2024
The role of cytochrome polymorphisms in primaquine metabolism and effects on its activity in radical cure of Plasmodium vivax infection
Objectives
This research will investigate how genetic variations affect primaquine metabolism and the prevention of recurrent vivax malaria.
Principal Institution
Principal Investigators / Focal Persons
Rationale and Abstract
Malaria is a mosquito-borne infection that can be life threatening. Globally there were 228 million cases and 405,000 deaths in 2018. One species, vivax malaria, can cause recurrent infection due to a dormant stage in the liver. The drug primaquine kills this dormant stage. However, recent studies have shown that genetic variations may limit primaquine effectiveness.
Thematic Categories
Date
Jan 2022
Total Project Funding
$98,091
Funding Details
National Health and Medical Research Council (NHMRC) Australia, Australia
Grant ID: 2014114
AUD 135,002
Project Site
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