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Last Updated: 19/06/2024
Control and release of memory CD4 + T cells by IL-27 in chronic malaria infection
Objectives
*Original title and abstract were machine translated from Japanese.
This study elucidates the regulatory mechanism of malaria immunological memory and paves the way for the development of innovative malaria vaccines that are effective in endemic areas.
It is known that it is difficult to acquire immunological memory in malaria and that the acquired immunological memory is easily lost, but the mechanism is not clear. It has been shown that in a mouse malaria red internal infection model, the regulatory cytokine IL-27 produced in the acute phase of infection negatively regulates the induction and maintenance of immunological memory CD4 + T cells. Therefore, the purpose of this study is to elucidate the regulatory mechanism of IL-27 in the induction and maintenance of memory CD4 + T cells at the cellular and molecular levels, and to clarify the role of memory CD + T cells in the defense against malaria reinfection.
Apr 2022 — Mar 2025
$147,672
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