Last Updated: 19/06/2024
Mechanism of the organelle discharge by malaria parasites during erythrocyte invasion
Objectives
*Original title and abstract were machine translated from Japanese.
To elucidate the mechanism of the organelle discharge by malaria parasites during erythrocyte invasion.
Principal Institution
Principal Investigators / Focal Persons
Rationale and Abstract
This study generated a recombinant murine malaria protozoa capable of inducibly knocking out a group of protozoan molecules expressed during the erythrocyte invasion phase, and induced release-invasion steps. Presence/absence and timing of molecular secretion, changes in intracellular Ca2+ concentration, and protein phosphorylation, etc., are used as indicators to identify the involvement of various molecules.
External reference
Thematic Categories
Date
Apr 2022 — Mar 2025
Total Project Funding
$146,578
Funding Details
Project Site
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