Array ( ) Array ( ) Array ( [0] => 30887 [1] => 20695 ) Array ( [0] => 30887 [1] => 20695 )

Last Updated: 19/06/2024

Comprehensive analysis of falciparum malaria-infected erythrocyte surface antigens and immunosuppressive receptor binding

Objectives

*Original title and abstract were machine translated from Japanese.

This study will create a RIFIN (a protozoan-derived erythrocyte surface antigen) expression library for all RIFINs and comprehensively analyze the binding to all inhibitory receptors to try to elucidate the whole molecular basis of the immune escape mechanism by RIFINs.

Principal Institution

Osaka University (OU), Japan

Principal Investigators / Focal Persons

Eiji Sakoguchi

Rationale and Abstract

Patients with falciparum malaria do not obtain sufficient acquired immunity even after repeated infections with protozoans, suggesting the existence of an active host immune escape mechanism by protozoans. So far, we have shown that RIFIN, a protozoan-derived erythrocyte surface antigen, suppresses the immune response through binding to multiple human immunosuppressive receptors and is involved in the host immune escape of the protozoan. There are more than 150 types of RIFIN genes on the protozoan genome, but the function of RIFIN has been clarified in less than 10% of the total, and the whole picture is still unknown.

External reference

Project details

Thematic Categories

Basic Science

Date

Apr 2022 — Mar 2024

Total Project Funding

$39,378

Funding Details

Japan Society for the Promotion of Science (JSPS), Japan

Grant ID: 22K15450

JPY 4.68M