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Last Updated: 14/01/2025
Optimising seasonal malaria chemoprevention and seasonal vaccination in childhood to address the resurgent malaria burden in Africa
Objectives
To understand how to:
- Maximise the impact of SMC as currently designed (e.g. by timing it more accurately in different areas).
- Modify the SMC strategy to make it more effective (e.g. by identifying the causes of severe malaria in the context of SMC).
- Use other control tools, including seasonally-targeted vaccination, alongside SMC.
- Understand how improving malaria prevention in childhood would affect naturally-acquired immunity.
Principal Institution
London School of Hygiene and Tropical Medicine (LSHTM), United Kingdom
Principal Investigators / Focal Persons
Rationale and Abstract
Almost half of the 435,000 malaria deaths each year occur in countries of the Sahel region of Africa, and the majority of these deaths occur during the three-four month rainy season. Monthly seasonal malaria chemoprevention (SMC) is highly effective in these areas, reducing malaria cases by 75-80% in trials, and malaria-specific mortality by 40-50% under programmatic conditions. However, malaria remains a leading cause of disease and death in several countries deploying SMC. Analysis of data from a comprehensive evaluation of SMC in 7 countries, an SMC trial in 20,000 children, and the first-ever trial of seasonally-targeted vaccination alongside SMC provides a unique opportunity to answer these questions. Mathematical models incorporating these results will enable malaria prevention packages to be optimised according to the local epidemiology.
External reference
Thematic Categories
Date
Jan 2021 — Jan 2026
Total Project Funding
$1.25M
Funding Details
Project Site
Deep Dives
Related Resources
