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Last Updated: 10/03/2023
Structural biology of malaria parasite invasion and antibodies-mediated inhibition
Objectives
To visualise the atomic details of the Rh5-CyRPA-Ripr complex during parasite invasion of erythrocytes and how antibodies neutralise this key protein complex.
Principal Institution
Walter and Eliza Hall Institute of Medical Research (WEHI), Australia
Principal Investigators / Focal Persons
Rationale and Abstract
Malaria results in significant mortality but an effective vaccine does not yet exist. The Rh5-CyRPA-Ripr complex is essential for malaria parasite to invade erythrocytes and is the leading vaccine candidate. We aim to visualise the atomic details of the Rh5-CyRPA-Ripr complex during parasite invasion of erythrocytes and how antibodies neutralise this key protein complex. This information will advance knowledge on malaria parasite invasion, which will help to design an effective malaria vaccine.
External reference
Thematic Categories
Date
Jan 2021 — Dec 2025
Total Project Funding
$1.14M
Funding Details
National Health and Medical Research Council (NHMRC) Australia, Australia
Grant number: 1196945
Project Site
Related Resources
