Boosting the impact of Seasonal Malaria Chemoprevention (SMC) through simultaneous screening and treatment of SMC-children’s roommates in Burkina Faso

ClinicalTrials.gov: NCT04816461

Study Type: Interventional (Clinical Trial)
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)

The study will be carried out in the Nanoro health district catchment area in Burkina Faso. This will be a randomized superiority trial. The unit of randomization will be the household and all eligible children from a household will be allocated to the same study group to avoid confusion. Households with 3 – 59 months old children will be assigned to either (i) control group (SMC alone) or (ii) intervention (SMC + roommates screening with standard HRP2-RDT and treatment if positive) or (iii) intervention (SMC + roommates screening with highly sensitive RDT and treatment if positive). The sample size will be 789 isolated households per arm, i.e. around 1,578 children and 2,630 roommates expected. They will be followed-up for 24 months to fully cover two consecutive malaria transmission seasons and then two SMC cycles. Children will be actively followed-up during the malaria transmission seasons while in the dry seasons the followed-up will be passive.

ClinicalTrials.gov - Project detailsL'Initiative - Project details

Drug-based Strategies
Impact of Interventions
Response Strategies
Vulnerable Populations

Jul 2021 — Jun 2023

$950,225

Burkina Faso

Seasonal Malaria Chemoprevention (SMC)
Targeted Test and Treat (TTaT) strategies
Tracking progress against the PMI Insights Research Priorities