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Last Updated: 29/06/2020
Mass drug administration with dihydroartemisinin-piperaquine and primaquine to reduce malaria in a moderate-low transmission setting in Senegal- a cluster randomized controlled trial
Objectives
The objective of the study is to determine the effect of three rounds of MDA with DHA-PQP and low-dose primaquine on village-level confirmed malaria case incidence when provided in the context of optimized control (proactive community case management + PBO nets), compared to optimized control interventions + SMC.
This study will be a two arm, cluster-randomized controlled trial to determine whether three rounds of MDA using antimalarials (DHA-PQP and primaquine) is associated with a greater reduction in confirmed malaria clinical incidence compared to optimized control over a follow-up period of one year post-MDA intervention. Randomization will occur at the level of the village. Twenty-two clusters will be enrolled in the comparison arm and 38 clusters enrolled in the MDA intervention arm for a total of 60 clusters (target population of 24,000). An 11:19 randomization will allow for a potential amendment to the MDA arm to add a novel vector control component in a subset of clusters (n=16) if one becomes available in Year 2.
Oct 2020 — Dec 2022
$2M
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