Last Updated: 09/10/2019

Cardio‑Safety of Dihydroartemisinin‑Piperaquine and Pharmacokinetics of Piperaquine Amongst Pregnant Women in Tanzania

Objectives

The aim of this project is to determine the cardio-safety of DP compared to SP amongst pregnant women in Tanzania since seems that DP will increase the time between the start of the Q wave and the end of the T wave in the heart’s electrical cycle, a phenomenon referred to as QT prolongation, in the study population.

Principal Institution

London School of Hygiene and Tropical Medicine (LSHTM), United Kingdom

Principal Investigators / Focal Persons

Matthew Chico

Partner Institutions

Kilimanjaro Christian Medical University College, Tanzania
National Institute for Medical Research (NIMR) Tanzania, Tanzania

Rationale and Abstract

Sulfadoxine-pyrimethamine (SP) is currently recommended by the World Health Organization for use as an intermittent preventive treatment against malaria in pregnancy (IPTp) in areas of moderate to high malaria transmission. However, in some locales malaria parasites have lost sensitivity to SP, compromising its protective effect. Dihydroartemisinin-piperaquine (DP) is a candidate replacement for SP.

Study Design

ClinicalTrials.gov Identifier: NCT02909712
Study Phase: Phase 2
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Basic Science

External reference

Clinical trial registration

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