Assess the micro-epidemiology of resistant falciparum malaria in SE Asia and perform and evaluate an intervention with targeted chemo-elimination through a modified mass drug administration approach (Lao People’s Democratic Republic)

• Drug & regimen: 3 monthly rounds of dihydroartemisinin-piperaquine (DP) (7 mg/kg dihydroartemisinin and 55 mg/kg piperaquine) for 3 days plus a single low dose of primaquine (PQ), mode of delivery being DOT administered by the TME staff
• Intervention by arms: Malaria elimination with DP + PQ (intervention) vs no chemo-elimination (control) 
• Concomitant interventions: LLINs, community engagement activities and strengthening of village malaria worker networks. The participants were reimbursed for their travel and opportunity costs
• Target & size population: 2 villages control and 2 villages intervention. 
• Inclusion criteria: Age ≥6 months, male or female
• Exclusion criteria: Pregnant or lactating women, anyone with acute health problems 
• Time of follow-up: 12 months
• Clinicaltrial.gov ID: NCT01872702

Type: Interventional
Allocation: Randomized
Intervention model: Parallel assignment
Masking: None (open label)
Primary purpose: Treatment

Drug-based Strategies

Apr 2013 — Oct 2016

Lao PDR

Targeted Chemo-elimination (TCE) to Eradicate Malaria in Areas of Suspected or Proven Artemisinin Resistance in Southeast Asia and South Asia

Mass Drug Administration (MDA)