Last Updated: 05/03/2018
Highly-sensitive RDT evaluation study in Haiti
Objectives
Two complementary studies were done in Haiti: a household survey, and an easy access group study. The main objective was to identify “hotspots” for malaria elimination interventions.
Highly-sensitive RDTs are evaluated both in the cross-sectional household survey and the early access group.
Primary objectives and outcomes at the individual levels:
- Evaluation of sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV) for detection of Pf infection, as compared with RDT, LAMP, PCR, and serology.
- Define HRP2 concentration and its correlation to parasitemia.
Primary objectives and outcomes at the population levels:
- Compare how different diagnostics perform in parasite surveys across a range of malaria transmission settings
- Evaluate the added value of the highly sensitive RDT over the conventional tests (RDT/Microscopy) in identifying malaria transmission foci.
CDC Foundation, United States
Tulane University, United States
This intervention aims to identify foci to map malaria transmission and trigger focal MDA.
Household survey population selection criteria: Study area included 2 communes in Haiti with total population size of 121,593. Primary sampling unit was the household. Selection of HH by simple random sampling in every 1km2 gridcell and weighted by population within gridcell. All residents of selected households were eligible for testing.
Two complementary studies were done: a household survey, and an easy access group study.
Oct 2016 — Dec 2017
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