Highly-sensitive RDT evaluation study in Haiti

Objectives

Two complementary studies were done in Haiti: a household survey, and an easy access group study. The main objective was to identify “hotspots” for malaria elimination interventions.

Highly-sensitive RDTs are evaluated both in the cross-sectional household survey and the early access group.

Primary objectives and outcomes at the individual levels:

• Evaluation of sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV) for detection of Pf infection, as compared with RDT, LAMP, PCR, and serology.
• Define HRP2 concentration and its correlation to parasitemia.

Primary objectives and outcomes at the population levels:

• Compare how different diagnostics perform in parasite surveys across a range of malaria transmission settings
• Evaluate the added value of the highly sensitive RDT over the conventional tests (RDT/Microscopy) in identifying malaria transmission foci.