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Last Updated: 08/08/2024

Assessment of larviciding efficacy for integrated vector control in the city of Yaoundé, Cameroon

Objectives

This project aims to assess the impact of larviciding for reducing malaria transmission in the city of Yaoundé using a new larvicide VectomaxTM combining both Bacillus thurigiensis israelensis and Bacillus sphaericus in single microparticles displaying longer residual effect. Specifically, the aims are:

  1. Map the spatial and temporal distribution and abundance of mosquitoes,
  2. Assess larviciding impact on malaria transmission intensity and malaria vectors bio-ecology,
  3. Assess larviciding impact in reducing the prevalence of pyrethroid resistance in An. gambiae s.l. populations.
Principal Investigators / Focal Persons

Christophe Antonio-Nkondjioa

Rationale and Abstract

Although over 60% of the population in Cameroon own Long Lasting Insecticide Nets (LLINs), vector control efforts across the country are hindered by the rapid expansion of pyrethroid resistance in vector populations. The situation is particularly concerning in urban settings (52% of the population) where mosquito are adapting to polluted sites and where unplanned urbanisation and the practice of urban agriculture provide breeding habitats for mosquitoes.To achieve the long term goal of malaria elimination in Africa, it is important to maintain the efficacy of existing control tools and to develop additional strategies for vector control. Larval control could be an important asset particularly in urban settings where breeding sites are few, fixed and findable. 

Mosquito species targeted and larviciding used: An. gambiae s.l. / VectomaxTM combining both Bacillus thurigiensis israelensis and Bacillus sphaericus

Study Design

Main outcome: densites of mosquitoes collected in houses using CDC light traps
Secondary outcomes: the entomological inoculation rate (EIR), the infection rate, the proportion of breeding sites with anopheline larvae, the proportion of breeding sites with late instar larvae

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